STUDY NAME
GOLD Study ID Gs0056639
Study Name Intestinal microbiome of Mouse lean and obese
Other Names Intestinal microbiome of Mouse lean and obese
NCBI Umbrella Bioproject Name
NCBI Umbrella Bioproject ID
Legacy ER Study ID 11639
Legacy GOLD ID Gm00071
Added By Nikos Kyrpides on 2007-11-27
Last Modified By Nikos Kyrpides on 2014-06-27
STUDY DESCRIPTION
PI Name Human Gut Community Users
Description The worldwide obesity epidemic is stimulating efforts to identify host and environmental factors that affect energy balance. Comparisons of the distal gut microbiota of genetically obese mice and their lean littermates, as well as those of obese and lean human volunteers have revealed that obesity is associated with changes in the relative abundance of the two dominant bacterial divisions, the Bacteroidetes and the Firmicutes. Here we demonstrate through metagenomic and biochemical analyses that these changes affect the metabolic potential of the mouse gut microbiota. Our results indicate that the obese microbiome has an increased capacity to harvest energy from the diet. Furthermore, this trait is transmissible: colonization of germ-free mice with an .obesemicrobiota. results in a significantly greater increase in total body fat than colonization with a .lean microbiota.. These results identify the gut microbiota as an additional contributing factor to the pathophysiology of obesity.
Relevance
Study Information Link
Study Information Link URL
Study Information Visibility Public
GOLD CLASSIFICATION
Ecosystem Host-associated
Ecosystem Category Mammals
Ecosystem Type Digestive system
Ecosystem Subtype Large intestine
Specific Ecosystem Fecal
Metagenomic Study Yes
STUDY COMPOSITION
Number of Biosamples 6
Number of Seq. Projects 6
Number of Analysis Projects 5
Number of Related Studies 0